What are the signs and symptoms of persistent pulmonary hypertension of the newborn (PPHN)?

Updated: Sep 03, 2019
  • Author: Kate A Tauber, MD; Chief Editor: Howard S Weber, MD, FSCAI  more...
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PPHN is often associated with the following signs and symptoms of perinatal distress:

  • Asphyxia

  • Tachypnea, respiratory distress

  • Respiratory acidosis

  • Loud, single second heart sound (S2) or a harsh systolic murmur (secondary to tricuspid regurgitation)

  • Low Apgar scores

  • Meconium staining

  • Cyanosis; poor cardiac function and perfusion

  • Systemic hypotension

  • Symptoms of shock

Idiopathic persistent pulmonary hypertension of the newborn can present without signs of acute perinatal distress. Marked lability in oxygenation is frequently part of the clinical history.

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