Which medications in the drug class Prostaglandins are used in the treatment of Coarctation of the Aorta?

Updated: Nov 20, 2018
  • Author: Syamasundar Rao Patnana, MD; Chief Editor: Stuart Berger, MD  more...
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Alprostadil (PGE1) promotes dilatation of the ductus arteriosus in infants with ductal-dependent cardiac abnormalities.

Alprostadil IV (Prostin VR Pediatric Injection)

Identical to the naturally occurring prostaglandin E1 (PGE1) and possesses various pharmacologic effects, including vasodilation and inhibition of platelet aggregation.

First-line medication used as palliative therapy to temporarily maintain patency of the ductus arteriosus before surgery. Beneficial in infants with congenital defects that restrict pulmonary or systemic blood flow and in patients who depend on a PDA for adequate oxygenation and lower-body perfusion. Produces vasodilation and increases cardiac output. Each 1-mL ampule contains 500 mcg/mL.

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