Which medications in the drug class Beta-adrenergic blocking agents are used in the treatment of Coarctation of the Aorta?

Updated: Nov 20, 2018
  • Author: Syamasundar Rao Patnana, MD; Chief Editor: Stuart Berger, MD  more...
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Answer

Beta-adrenergic blocking agents

These agents inhibit chronotropic, inotropic, and vasodilatory responses to beta-adrenergic stimulation. Preoperative hypertension can be treated effectively with beta-blockers.

Metoprolol (Lopressor)

Selective beta1-adrenergic receptor blocker that decreases automaticity of contractions. During IV administration, carefully monitor BP, heart rate, and ECG. When considering conversion from IV to PO dosage forms, use ratio of 2.5 mg PO to 1 mg IV metoprolol.

Esmolol (Brevibloc)

Ultra–short-acting beta2-blocker. Particularly useful in patients with labile arterial pressure, especially if surgery is planned, because it can be discontinued abruptly, if necessary. May be useful as a means to test beta-blocker safety and tolerance in patients with history of obstructive pulmonary disease who are at uncertain risk for bronchospasm from beta-blockers. Elimination half-life is 9 min.

Labetalol (Normodyne, Trandate)

Blocks alpha-aderenergic, beta1-aderenergic, and beta2-aderenergic receptor sites, decreasing BP.

Propranolol (Inderal, Betachron E-R)

Class II antiarrhythmic nonselective beta-adrenergic receptor blocker. Has membrane-stabilizing activity and decreases automaticity of contractions. Not suitable for emergency treatment of hypertension.

Atenolol (Tenormin)

Selectively blocks beta1-receptors with little or no effect on beta2-receptors.


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