What is the role of restrictive LV physiology the prognosis of coarctation of the aorta (CoA)?

Updated: Nov 20, 2018
  • Author: Syamasundar Rao Patnana, MD; Chief Editor: Stuart Berger, MD  more...
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A study by Oliver et al indicated that in young adults who underwent aortic coarctation repair in childhood, the greatest risk factor for heart failure or cardiovascular death is pulmonary hypertension related to restrictive LV physiology. The study involved 159 adults who underwent aortic coarctation repair at mean age 4.1 years. The investigators found that those individuals with a pulmonary artery systolic pressure of over 40 mm Hg were at the greatest risk of death or of being admitted to the hospital for heart failure. Using logistic regression analysis, they also found that pulmonary hypertension in the adults studied was predicted primarily by restrictive LV physiology. [18]

The study did not find heart failure or death to be statistically associated with recoarctation, systemic hypertension, intracardiac lesions, or aortic aneurysm or with treatment with beta blockers or ACE inhibitors/angiotensin receptor blockers. [18]

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