What causes anomalous left coronary artery from the pulmonary artery (ALCAPA)?

Updated: Aug 10, 2020
  • Author: Mary C Mancini, MD, PhD, MMM; Chief Editor: Syamasundar Rao Patnana, MD  more...
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Answer

Inheritance is not a factor for anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA). For example, if two family members are affected, the fact that they are within the same family did not have a role in their development of the condition. The condition is generally considered to be on the basis of multifactorial inheritance, similar to other congenital heart defects.

In utero exposure to teratogens, chromosomal abnormalities, or other risk factors are unrelated to ALCAPA.

Other congenital cardiac defects, such as patent ductus arteriosus, ventricular septal defect, tetralogy of Fallot, or coarctation of the aorta, rarely may be associated with ALCAPA. No specific association with any noncardiac anomalies is noted. [4]


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