What is the efficacy of indomethacin and ibuprofen in the treatment of patent ductus arteriosus (PDA)?

Updated: Nov 20, 2018
  • Author: Luke K Kim, MD; Chief Editor: Stuart Berger, MD  more...
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Answer

A meta-analysis by Ohlssen et al found ibuprofen is as effective as indomethacin in closing a patent ductus arteriosus (PDA) and reduces the risk of necrotizing enterocolitis and transient renal insufficiency associated with indomethacin. [15]

A meta-analysis by Jones et al confirmed that both indomethacin and ibuprofen treatments promote patent ductus arteriosus (PDA) closure better than placebo. [16] Ibuprofen and indomethacin appear to be equally effective, with similar rates of complications after therapy except for the development of chronic lung disease (30% greater risk in ibuprofen treatment arm). However, the investigators did not discuss if chronic lung disease might have reflected selection bias or if the degree of chronic lung disease in these patients resulted in poorer long-term outcomes. [16]


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