What are the pharmacologic treatment options for patent ductus arteriosus (PDA)?

Updated: Nov 20, 2018
  • Author: Luke K Kim, MD; Chief Editor: Stuart Berger, MD  more...
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Answer

The premature neonate with a significant patent ductus arteriosus (PDA) is usually treated with intravenous (IV) indomethacin or ibuprofen. [8] This has been quite successful in most patients. Whether results with IV indomethacin are superior to those with surgical closure of the patent ductus arteriosus (PDA), even in the premature neonate in whom the safety of the surgery is a concern, is unclear. [9]

IV indomethacin was the standard drug treatment. Then, IV ibuprofen was approved by the US Food and Drug Association (FDA). Although ibuprofen and indomethacin are equally effective, other differences are noted: Indomethacin appears to decrease the incidence of intraventricular hemorrhage, whereas ibuprofen has less renal toxicity.


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