Which histologic findings are characteristic of patent ductus arteriosus (PDA)?

Updated: Nov 20, 2018
  • Author: Luke K Kim, MD; Chief Editor: Stuart Berger, MD  more...
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Answer

Very rarely, a biopsy may be performed in severe cases. Histologic findings include the following:

  • The walls of the ductus contain intima, media, and adventitia

  • The medial layer of the structure is composed of longitudinal smooth muscle in the inner layer and circumferentially arranged smooth muscle in the outer layers; this is in contrast to true arterial structures, which contain a medium primarily composed of circumferential elastic fibers; these layers of smooth muscle contain concentric loose lamina of elastic tissue and a network of tiny thin-walled vessels.

  • The intimal layer is irregularly thickened and contains a considerable amount of mucoid material


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