Which factors affect the prognosis of ductus arteriosus (PDA)?

Updated: Nov 20, 2018
  • Author: Luke K Kim, MD; Chief Editor: Stuart Berger, MD  more...
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Answer

Morbidity and mortality rates are directly related to the flow volume through the ductus arteriosus. A large patent ductus arteriosus (PDA) may cause congestive heart failure (CHF); if left untreated for a long period, pulmonary hypertension may develop. Occasionally, the ductus arteriosus patency can be intermittent.

Low birth weight premature infants

As many as 20% of neonates with respiratory distress syndrome have patent ductus arteriosus (PDA). In babies who are less than 1500 g at birth, many studies show the incidence of a patent ductus arteriosus (PDA) to exceed 30%. The increased patency in these groups is thought to be due to both hypoxia in babies with respiratory distress and immature ductal closure mechanisms in premature babies.

Premature babies, particularly low birth weight neonates, are more likely to have problems related to patent ductus arteriosus (PDA). Spontaneous closure of the patent ductus arteriosus (PDA ) in premature neonates is common, but respiratory distress and impaired systemic oxygen delivery (CHF) often drive the need for therapy to effect ductal closure in this group. Low birth weight neonates with a patent ductus arteriosus (PDA) are more likely to develop chronic lung disease.


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