What is the role of genetics in the etiology of patent ductus arteriosus (PDA)?

Updated: Nov 20, 2018
  • Author: Luke K Kim, MD; Chief Editor: Stuart Berger, MD  more...
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Answer

Familial cases of patent ductus arteriosus (PDA) have been recorded, but a genetic cause has not been determined. In infants born at term who have a persistent patent ductus arteriosus (PDA), the recurrence rate among siblings is 5%. Some early evidence suggests that as many as one third of cases are caused by a recessive trait labeled PDA1, located on chromosome 12, at least in some populations.


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