How do volume-pressure relationships affect patent ductus arteriosus (PDA)?

Updated: Nov 20, 2018
  • Author: Luke K Kim, MD; Chief Editor: Stuart Berger, MD  more...
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Answer

Further progression of disease is dependent on volume and pressure relationships, as follows:

  • Volume = pressure/resistance

  • High volume yields increasing pulmonary artery pressures, eventually producing endothelial and muscular changes in the vessel wall

  • These changes may eventually lead to pulmonary vascular obstructive disease (PVOD), a condition of resistance to pulmonary blood flow that may be irreversible and will preclude definitive repair


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