What is the progression of patent ductus arteriosus (PDA) if left untreated?

Updated: Nov 20, 2018
  • Author: Luke K Kim, MD; Chief Editor: Stuart Berger, MD  more...
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Spontaneous closure after 5 months is rare in the full-term infant. Left untreated, patients with a large patent ductus arteriosus (PDA) are at risk to develop Eisenmenger Syndrome, in which the PVR can exceed SVR, and the usual left-to-right shunting reverses to a right-to-left direction. At this stage, the PVR is irreversible, closure of the patent ductus arteriosus (PDA) is contraindicated, and lung transplantation may be the only hope for long-term survival.

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