Which medications in the drug class Intravenous immunoglobulin are used in the treatment of Pediatric Severe Combined Immunodeficiency?

Updated: Apr 28, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Harumi Jyonouchi, MD  more...
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Answer

Intravenous immunoglobulin

IVIg is the usual choice. It is derived from human plasma and is composed of all 4 immunoglobulin G (IgG) subclasses. The antibody distribution of IVIg is approximately the same as that of human serum. IVIg can be used to restore antibody levels until the B-cell system is restored with BMT. However, long-term use fails to change the terminal course of SCID.

Immune globulin IV (IGIV) (Asceniv, Bivigam, Carimune)

IVIg is a human serum fraction that contains IgG. It provides IgG antibodies that the patient cannot make. The therapeutic function is passive immunization to prevent infection.


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