Which medications in the drug class Enzymes, Metabolic are used in the treatment of Pediatric Severe Combined Immunodeficiency?

Updated: Apr 28, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Harumi Jyonouchi, MD  more...
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Answer

Enzymes, Metabolic

Replacement enzymes are used in patients with adenosine deaminase (ADA) deficiency and SCID who benefit from BMT. Improved immune function and clinical response are observed with polyethylene glycol–conjugated ADA (PEG-ADA) replacement therapy for ADA deficiency.

Elapegademase (Revcovi)

Elapegademase a recombinant adenosine deaminase based on bovine amino acid sequence and conjugated to PEG. It is indicated for treatment of ADA severe combined immune deficiency (ADA-SCID) in pediatric and adult patients.


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