Which medications in the drug class Sulfonamides are used in the treatment of Pediatric Severe Combined Immunodeficiency?

Updated: Apr 28, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Harumi Jyonouchi, MD  more...
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Answer

Sulfonamides

Antibiotics are used in the primary treatment and prophylaxis of Pneumocystis jiroveci (carinii) pneumonia (PCP).

Trimethoprim-sulfamethoxazole (Septra DS, Bactrim DS, Cotrim DS)

Trimethoprim-sulfamethoxazole is used because of low levels of T cells or poor T-cell function in children with SCID. It inhibits bacterial growth by inhibiting synthesis of dihydrofolic acid. Its antibacterial activity affects common urinary tract pathogens, except Pseudomonas aeruginosa. Each 5 mL vial for intravenous (IV) administration contains 80 mg of trimethoprim and 400 mg of sulfamethoxazole. Each 5 mL vial must be added to 125 mL of 5% dextrose in water. Please consult the hospital pharmacist when preparing this medication.


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