What is the global prevalence of severe combined immunodeficiency (SCID)?

Updated: Apr 28, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Harumi Jyonouchi, MD  more...
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Answer

International frequency is similar to that of the United States. XL-SCID, like other X-linked disorders, has a higher frequency in populations with increased consanguinity.

Although SCID is notoriously underreported, several countries now maintain registries of patients with primary immunodeficiency diseases. In Australia, the estimated prevalence of SCID is 0.15 case per 100,000; in Norway, 0.045 case per 100,000; and in Switzerland, 0.47 case per 100,000. In Sweden, SCID occurs in 2.43 of every 100,000 live births.


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