Which medications in the drug class Corticosteroid oral inhalers are used in the treatment of Mold Allergy?

Updated: Sep 18, 2017
  • Author: Shih-Wen Huang, MD; Chief Editor: Harumi Jyonouchi, MD  more...
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Answer

Corticosteroid oral inhalers

These are potent anti-inflammatory agents because of their effects on several cell types (eg, mast cells, eosinophils, neutrophils, macrophages, lymphocytes) and on the production and secretion of mediators (eg, histamine, eicosanoids, leukotriene, cytokines) in inflammatory process. Inhalers listed below are valuable for the treatment of mild-to-moderately persistent or severe forms of allergic asthma and are used as supplemental therapy for ABPA, ABPM, and EAA. Oral inhaled corticosteroids allow avoidance of severe adverse effects associated with systemic corticosteroids.

Fluticasone inhaled

Fluticasone inhaled is indicated for the maintenance and treatment of asthma as prophylaxis; it is also used in patients requiring long-term systemic corticosteroid treatment to attempt gradual tapering and discontinuation of oral corticosteroids. It is available as Flovent MDI (44, 110, or 220 mcg per actuation), Flovent Rotadisk (50, 100, or 250 mcg per actuation), and dry powder in blister packs for inhalation with an inhalation device.

Budesonide inhaled (Pulmicort Flexhaler)

Budesonide inhaled inhibits bronchoconstriction mechanisms, produces direct smooth muscle relaxation, and may decrease the number and activity of inflammatory cells, in turn decreasing airway hyperresponsiveness. It has extremely potent vasoconstrictive and anti-inflammatory activity. It alters the level of inflammation in airways by inhibiting multiple types of inflammatory cells and decreasing the production of cytokines and other mediators. It decreases inflammation by suppressing the migration of polymorphonuclear leukocytes and reversing capillary permeability. It is used for the treatment of allergic rhinitis.

It is available as Pulmicort Flexhaler (90 mcg per actuation or 180 mcg per actuation delivers 80 mcg per inhalation or 160 mcg/inhalation) or Pulmicort Respules inhalation suspension (0.25 mg/2 mL, 0.5 mg/2 mL).

Triamcinolone inhaled (Azmacort)

Triamcinolone inhaled is indicated for the maintenance and treatment of asthma as prophylaxis; it is also used in patients requiring long-term systemic corticosteroid treatment to attempt gradual tapering and discontinuation of oral corticosteroids. It is available as Azmacort (75 mcg per actuation) and MDI with an attached Aerochamber device.


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