Which medications in the drug class Systemic corticosteroids are used in the treatment of Mold Allergy?

Updated: Sep 18, 2017
  • Author: Shih-Wen Huang, MD; Chief Editor: Harumi Jyonouchi, MD  more...
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Answer

Systemic corticosteroids

These are potent anti-inflammatory agents because of their effects on many cell types (eg, mast cells, eosinophils, neutrophils, macrophages, basophils, lymphocytes) and on the production and secretion of mediators (eg, histamine, eicosanoids, leukotrienes, cytokines) in inflammation. Many conditions related to mold allergy (eg, allergic asthma, ABPA, AFS, ABPM, EAA) require systemic corticosteroids from the onset of disease.

When disease activity decreases, reducing the dose to the lowest effective level and trying to further taper it to an every-other-day schedule are advisable. Also, a oral inhaled corticosteroid may be used to replace a systemic steroid to reduce adverse effects.

For allergic asthma, systemic corticosteroids are indicated when patients have a severe form of asthma resistant to other forms of therapy.

Prednisone

Prednisone remains the mainstay oral systemic corticosteroid. Starting doses in each condition or different stages of same disease may differ. The main concerns with systemic corticosteroids, especially with long-term use, are adverse effects, which are more apparent than those of oral inhaled corticosteroids. Various tablet strengths and liquids are available to customize doses and ease tapering.

Prednisolone (Pediapred, Prelone, Millipred)

Starting doses in each condition or in different stages of the same disease may differ. The main concern with systemic corticosteroids, especially with long-term use, is their adverse effects, which are more apparent than those of oral inhaled corticosteroids. Various tablet strengths and liquids are available to enable customized doses and tapering ease.


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