Which medications in the drug class Leukotriene antagonists/5-lipoxygenase inhibitors are used in the treatment of Mold Allergy?

Updated: Sep 18, 2017
  • Author: Shih-Wen Huang, MD; Chief Editor: Harumi Jyonouchi, MD  more...
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Answer

Leukotriene antagonists/5-lipoxygenase inhibitors

In asthma, leukotriene is an important mediator released in the airway that causes constriction of smooth muscle. This is most apparent in a delayed-phase reaction. Therefore, use of leukotriene antagonists is an important part of treatment to control asthma. These agents are indicated for forms of asthma ranging from mild intermittent to severe. For children, it is a valuable treatment for the night cough or wheeze. Inhibition of lipoxygenase reduces production of leukotriene at peripheral tissue and achieves results similar to those of leukotriene antagonists.

Montelukast (Singulair)

Montelukast is a leukotriene receptor antagonist indicated for the long-term treatment of asthma. It is available as 4- and 5-mg chewable tablets, 4-mg granules, 10-mg oral tablets.

Zafirlukast (Accolate)

Zafirlukast is indicated for prophylaxis and long-term treatment of asthma. It is a leukotriene receptor antagonist.

Zileuton (Zyflo, Zyflo CR)

Zileuton is indicated for prophylaxis and long-term treatment of asthma. It is a 5-lipoxygenase inhibitor.


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