Which histologic findings are characteristic of mold-related extrinsic allergic alveolitis (EAA)?

Updated: Sep 18, 2017
  • Author: Shih-Wen Huang, MD; Chief Editor: Harumi Jyonouchi, MD  more...
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Answer

In patients with acute and subacute forms of EAA, lung biopsy specimens may reveal noncaseating granulomas with foreign-body giant cells, large numbers of lymphocytes, foamy macrophages, and bronchiolitis fibrosa obliterans associated with centrolobular pneumonia.

Vasculitis is rare.

In chronic disease, the lesions become nonspecific as the granulomas disappear and fibrosis supervenes.

Interstitial pneumonitis persists, and bronchiolitis fibrosa obliterans may lead to peripheral destruction of alveolar walls.

The overall picture is a variable mixture of scarring pneumonitis, honeycombing, and emphysema.


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