Which histologic findings are characteristic of mold-related allergic bronchopulmonary aspergillosis (ABPA) and allergic bronchopulmonary mycosis (ABPM)?

Updated: Sep 18, 2017
  • Author: Shih-Wen Huang, MD; Chief Editor: Harumi Jyonouchi, MD  more...
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Answer

The bronchi contain thick, tenacious mucus with fibrin, eosinophils, and Charcot-Leyden crystals.

Aspergillus (in ABPA) or other fungi hyphae may be identified with special stains. No invasion of the bronchial wall occurs despite a large number of hyphae.

The upper lobe bronchi may be dilated and partially collapsed, whereas smaller bronchi are occluded with mucus.

Bronchial wall inflammation with mononuclear cells and/or eosinophils often is observed.

Some changes from asthma are expected to be apparent.


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