Which histologic findings are characteristic of mold-related allergic fungal sinusitis (AFS)?

Updated: Sep 18, 2017
  • Author: Shih-Wen Huang, MD; Chief Editor: Harumi Jyonouchi, MD  more...
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Answer

The swollen mucosa is covered with thick sinus secretions that appear as allergic mucin and are loaded with degranulating eosinophils. Charcot-Leyden crystals can be found. Hyphae of the offending fungi should be visible.

Sinus mucosal tissue characteristically shows intense chronic inflammation with a large number of eosinophils.

In 6 children with allergic Aspergillus sinusitis, all had multiple sinuses densely packed with greenish black, inspissated mucin.


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