Which histologic findings are characteristic of mold-related allergic rhinitis and conjunctivitis?

Updated: Sep 18, 2017
  • Author: Shih-Wen Huang, MD; Chief Editor: Harumi Jyonouchi, MD  more...
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Answer

In acute cases, submucosal cellular infiltration is limited.

Edema and vasodilation are obvious, indicating an immediate phase reaction. In subacute or recurrent rhinitis, goblet cells are increased.

Eosinophil, neutrophil, and plasma-cell infiltration is significant in the submucosal area.

In chronic cases, epithelial cells are often severely damaged or disrupted, exposing the submucosal layer. More mononuclear cells are found in the submucosa. Increased deposition of collagens is present. Immunohistochemical studies reveal heavy deposition of eosinophil cationic protein in the submucosa.


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