What has been learned from animal models of mold allergic airway diseases?

Updated: Sep 18, 2017
  • Author: Shih-Wen Huang, MD; Chief Editor: Harumi Jyonouchi, MD  more...
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Answer

Animal models of disease are an invaluable tool for contributing to the understanding of the pathophysiology of allergic airway diseases. Hoselton et al recently reported such model using A fumigatus. Balb/c mice were challenged with A fumigatus via intranasal inoculation. They were previously sensitized with intraperitoneal injections with soluble A fumigatus in alum. After a single challenge of inhalation, allergic pulmonary inflammation and airway hyperresponsiveness were significantly increased compared with control animals. Later, a significant increase in epithelial thickness, global cell metaplasia, and peribronchial collagen deposition was noted. The authors concluded this was the first time they demonstrated that the consistent development of fibrosis and smooth muscle changes accompany exposure to inhaled fungal conidia in a mouse model.


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