Which pathogen-derived products may be therapeutic for mold allergy?

Updated: Sep 18, 2017
  • Author: Shih-Wen Huang, MD; Chief Editor: Harumi Jyonouchi, MD  more...
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Answer

Several pathogen-derived products have been shown to possess therapeutic potentials for allergic diseases. It has been suggested the glucan of the wall component of a variety of fungi may have that potential. Kawashima et al, using an animal study, examined the effect of curdlan, a linear beta-(1-3)-glucan, on the development of allergic airway inflammation. [9] They found that an injection of curdlan significantly inhibited Ag-induced eosinophilic recruitment and Th2 cytokine productions in the airways. They found that STAT6-aided IL-10 production by CD4+ T cells in the presence of curdlan contributed to this process. It underscores the therapeutic potential of curdlan for various fungus-related allergic diseases.


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