What is the role of anti-CD20 monoclonal antibodies in the treatment of common variable immunodeficiency (CVID)?

Updated: Oct 16, 2018
  • Author: C Lucy Park, MD; Chief Editor: Harumi Jyonouchi, MD  more...
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Answer

Successful treatment of autoimmune thrombocytopenia and neutropenia using anti-CD20 monoclonal antibody administration was reported. Anti-TNF monoclonal antibody, infliximab, has been used successfully in the treatment of cutaneous granulomas in a patient with common variable immunodeficiency. A review of patients with granulomas reported no benefit with rituximab, etanercept, or infliximab in the treatment of granulomatous disease.


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