What is the basis for a diagnosis of common variable immunodeficiency (CVID)?

Updated: Oct 16, 2018
  • Author: C Lucy Park, MD; Chief Editor: Harumi Jyonouchi, MD  more...
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The diagnosis of CVID is based on the following:

  • Defective functional antibody formation (eg, low IgG response to vaccination)

  • Decreased (not absent) serum immunoglobulin (Ig)G and IgA levels (usually)

  • Decreased serum IgM level (generally, but not invariably)

  • Exclusion of other known causes of antibody deficiency

See Workup for more detail.

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