What are the signs and symptoms of common variable immunodeficiency (CVID)?

Updated: Oct 16, 2018
  • Author: C Lucy Park, MD; Chief Editor: Harumi Jyonouchi, MD  more...
  • Print
Answer

Clinical manifestations of CVID include the following:

  • Recurrent infections

  • Autoimmune disease

  • Lymphoid hyperplasia

  • Granulomatous diseases

  • Malignancy

Recurrent infections may include the following:

  • Pyogenic sinopulmonary tract infection, especially after puberty

  • In some cases, infections with unusual organisms (eg, Pneumocystis jiroveci, mycobacteria, various fungi)

  • Mycoplasma pneumoniae infections in the urinary tract, joints, and deep abscesses

  • Persistent diarrhea and malabsorption caused by Giardia lamblia

  • Severe and recurrent infections with herpes simplex

  • Unusual enteroviral infections with a chronic meningoencephalitis and a dermatomyositis-like illness; presenting symptoms are either acute or insidious, with signs of encephalitis, seizures, headache, sensory motor disturbances, and personality changes

Autoimmune conditions in patients with CVID are as follows:

  • Idiopathic thrombocytopenic purpura (ITP)

  • Hemolytic anemia

  • More rarely, autoimmune neutropenia

  • Other solid organ–specific autoimmune diseases (eg, pernicious anemia, thyroid diseases, vitiligo)

  • Insulin-dependent diabetes

  • Psoriasis

  • Systemic lupus erythematosus

  • Rheumatoid arthritis

  • Juvenile rheumatoid arthritis

  • Uveitis

  • Severe gastroenteropathy with severe malabsorption, nodular lymphoid hyperplasia, and chronic inflammatory bowel disease (eg, ulcerative colitis, Crohn disease)

Physical examination findings may include the following:

  • Generalized lymphadenopathy and splenomegaly

  • Failure to thrive in young children, secondary to frequent infection and increased energy expenditure

See Clinical Presentation for more detail.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!