Which mechanisms may have a role in the pathophysiology of migraine-associated vertigo?

Updated: Jan 18, 2019
  • Author: Aaron G Benson, MD; Chief Editor: Arlen D Meyers, MD, MBA  more...
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Answer

Answer

Some authors have suggested that peripheral cochleovestibular dysfunction in migraine patients may be attributed to vasospasm of the internal auditory artery causing ischemia to the labyrinth. [19] Furthermore, Lee et al have reported a positive association of the progesterone receptor (PGR) with migraine-associated vertigo. [20]

Serotonin (5-hydroxytryptamine [5-HT]) has also been found to be an important substrate in the development of migraine. Interestingly, 5-HT has direct effects on the firing rate of vestibular nucleus neurons. The serotonergic and the peptidergic pathways possibly play a role in the development of the short and prolonged periods of dizziness in migraine-associated vertigo.


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