What is sialadenosis (sialosis) relative to parotitis?

Updated: May 04, 2020
  • Author: Jerry W Templer, MD; Chief Editor: Arlen D Meyers, MD, MBA  more...
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In this disorder, both parotid glands may be diffusely enlarged with only modest symptoms. Patients are aged 20-60 years at onset, and the sexes are equally involved. The glands are soft and nontender. Biopsy shows the acinar cells to be enlarged to almost twice the normal diameter and the cytoplasm packed with enzyme granules. The cause is unknown, but inappropriate autonomic nervous system stimuli are frequently suggested. Approximately half of the patients have endocrine disorders such as diabetes, nutritional disorders such as pellagra or kwashiorkor, or have taken drugs such as guanethidine, thioridazine, or isoprenaline. If the symptoms are mild, treatment is not required. If the glands are disfiguring, partial parotidectomy should improve the appearance.

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