What is the role of positron emission tomography/CT (PET/CT) scanning in the diagnosis of submandibular sialadenitis/sialadenosis?

Updated: May 12, 2020
  • Author: Adi Yoskovitch, MD, MSc; Chief Editor: Arlen D Meyers, MD, MBA  more...
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Answer

A retrospective cohort study by Takano et al indicated that 18F-fluorodeoxyglucose (FDG) positron emission tomography/CT (PET/CT) scanning may, when combined with serologic and clinical evaluation, be able to diagnose IgG4-SS. The investigators found that in 98% of patients with IgG4-SS, FDG uptake was increased in the submandibular gland. The diagnostic sensitivity, specificity, and accuracy of high FDG uptake by the submandibular gland in combination with a serum IgG4 level of 135 mg/dL or higher were reported to be 96.9%, 90.0%, and 86.4%, respectively. [10]


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