What is the role of medications in the treatment of piriformis syndrome?

Updated: Dec 21, 2018
  • Author: Shishir Shah, DO; Chief Editor: Sherwin SW Ho, MD  more...
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Answer

NSAIDs are mentioned not in this section because of the lack of any documented or studied effectiveness in piriformis syndrome. However, physicians may use any number of these agents, on the basis of their experience in managing LBP or neuropathies.

Naja et al investigated whether clonidine-bupivacaine nerve-stimulator guided injections are effective in achieving long-lasting pain relief in piriformis syndrome compared with bupivacaine guided injection. [11] Significantly lower pain scores and analgesic consumption were observed with bupivacaine-clonidine compared with bupivacaine-saline. Additionally, pain at 6 months was significantly greater in the bupivacaine-saline group (78%) compared with the bupivacaine-clonidine group (8%). [11]


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