Which medications in the drug class Antibiotics, Other are used in the treatment of Tonsillitis and Peritonsillar Abscess?

Updated: Apr 06, 2020
  • Author: Udayan K Shah, MD, FACS, FAAP; Chief Editor: Arlen D Meyers, MD, MBA  more...
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Antibiotics, Other

Antibiotic therapy must be comprehensive and cover all likely pathogens in the context of this clinical setting.

Penicillin G benzathine (Bicillin L-A)

Penicillin interferes with synthesis of cell wall mucopeptides during active multiplication, which results in bactericidal activity.

Clarithromycin (Biaxin)

Clarithromycin inhibits bacterial growth, possibly by blocking dissociation of peptidyl tRNA from ribosomes causing RNA-dependent protein synthesis to arrest. It is a semisynthetic macrolide with twice-daily dosing.

Clindamycin (Cleocin)

Clindamycin is an oral or parenteral antibiotic that is used for the treatment of anaerobic or susceptible streptococcal, pneumococcal, or staphylococcal species. It is considered to have good absorption into the bloodstream in both oral and parenteral forms.


Vancomycin is indicated for patients who cannot receive or have failed to respond to penicillins and cephalosporins or who have infections with resistant staphylococci. To avoid toxicity, the current recommendation is to assay vancomycin trough levels after the third dose, drawn 30 minutes prior to the next dosing. Use creatinine clearance (CrCl) to adjust the dose in patients diagnosed with renal impairment. It is used in conjunction with gentamicin for prophylaxis in penicillin-allergic patients undergoing gastrointestinal or genitourinary procedures.

Rifampin (Rifadin)

Rifampin is an inhibitor of bacterial DNA-dependent RNA polymerase activity.

Amoxicillin (Moxatag)

Amoxicillin is an oral antibiotic with specific activity against penicillin-resistant organisms; it is often combined with the beta-lactamase inhibitor clavulanic acid.

Amoxicillin and clavulanate (Augmentin, Amoclan, Augmentin XR)

Amoxicillin is a third-generation aminopenicillin. Combined with the beta-lactam clavulanic acid, it is less susceptible to degradation by beta-lactamases produced by microorganisms.

Metronidazole (Flagyl)

Metronidazole is effective in patients with tonsillitis and mononucleosis, for shortening fever duration and reducing tonsillar size, and in management of acute episodes of nonstreptococcal tonsillitis.

Ampicillin and sulbactam (Unasyn)

This is a drug combination of a beta-lactamase inhibitor with ampicillin. It interferes with bacterial cell wall synthesis during active replication, causing bactericidal activity against susceptible organisms. It is an alternative to amoxicillin/clavulanate if the patient is unable to take medication orally.

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