What is the role of protriptyline in the treatment of sleep-disordered breathing (SDB)?

Updated: Feb 13, 2020
  • Author: Vittorio Rinaldi, MD; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
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Protriptyline, a tricyclic antidepressant, is the medication most studied in the treatment of SDB and does yield improvement in patients with this condition. This effect, however, appears to be mainly due to suppression of rapid-eye-movement (REM) sleep. Because SDB is often most severe during REM sleep, less REM sleep can mean fewer apneas.

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