What is the role of oral vitamin B-12 in the treatment of recurrent aphthous stomatitis (RAS)?

Updated: May 11, 2020
  • Author: Jaisri R Thoppay, DDS, MBA, MS; Chief Editor: Arlen D Meyers, MD, MBA  more...
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Oral vitamin B-12 may significantly reduce or eliminate RAS recurrences. For example, a randomized, double-blind, placebo-controlled study by Volkov et al found that in patients taking 1000 μg of sublingual vitamin B-12 daily for 6 months, there was a significant decrease in the number of ulcers and level of pain, as well as in the duration of outbreaks, at 5 and 6 months no matter what the patients' initial B-12 blood levels had been. Moreover, during the sixth month of treatment, 74.1% of the patients taking B-12 achieved "no aphthous ulcers status," compared with 32.0% of patients in the control group. [17]

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