What are histologic findings characteristic of recurrent aphthous stomatitis (RAS)?

Updated: May 11, 2020
  • Author: Jaisri R Thoppay, DDS, MBA, MS; Chief Editor: Arlen D Meyers, MD, MBA  more...
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The histology of RAS is nonspecific. The ulcer is depressed well below the surface, and the inflammation extends deeply. The surface of the ulcer is covered by a fibrinous exudate infiltrated by polymorphs. Beneath is a layer of granulation tissue with dilated capillaries and edema. Deeper still is a repair reaction, with fibroblasts in the surrounding connective tissue laying down fibrous tissue.

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