What is the role of exogenous antigens in the etiology of recurrent aphthous stomatitis (RAS)?

Updated: May 11, 2020
  • Author: Jaisri R Thoppay, DDS, MBA, MS; Chief Editor: Arlen D Meyers, MD, MBA  more...
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Hypersensitivity reactions to exogenous antigens other than gluten do not have a significant etiologic role in RAS, and associations with atopy are inconsistent. Moreover, a consistent association between aphthous ulceration and psychological illness, zinc deficiency, or sex hormone levels is unlikely.

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