What is the prognosis of acute invasive fungal sinusitis?

Updated: Mar 17, 2020
  • Author: Hassan H Ramadan, MD, MSc; Chief Editor: Arlen D Meyers, MD, MBA  more...
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Answer

This condition carries a poor prognosis. Mortality rate is reported at 50%, even with aggressive surgical and medical treatment. Relapses are common during subsequent episodes of neutropenia. Treatment with systemic antifungals as prophylaxis is indicated in cases of neutropenia.

A retrospective study by Green et al of 14 immunocompromised pediatric patients with invasive fungal sinusitis indicated that while absolute neutrophil count was a significant prognostic factor in these children, patient age and gender, cause of immunodeficiency, and fungal agent were not. [19]

A literature review by Smith et al suggested presentation with facial pain to be a negative predictor of overall mortality (odds ratio = 0.296) in pediatric patients with invasive fungal sinusitis. [20]


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