What is the role of receptors throughout the body in the pathophysiology taste and smell disorders?

Updated: Jan 08, 2021
  • Author: Eric H Holbrook, MD; Chief Editor: Arlen D Meyers, MD, MBA  more...
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Ongoing research has identified odor and taste receptors in surprising places, including skeletal muscle, brain, respiratory tract, and GI tract. Evidence shows taste receptors present from the stomach to the colon function in nutrient sensing and gut motility. [10, 11] The exact role of these receptors in regions other than the nose and mouth needs to be further elucidated. Research has focused on the presence of bitter taste receptors (TAS2Rs; also known as T2Rs) expressed throughout the body, with differing mechanisms used by these receptors to mediate various nontaste functions; [12]  TAS2Rs provide targets for novel therapeutic interventions.

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