What is the pathophysiology of taste perception in taste disorders?

Updated: Dec 11, 2018
  • Author: Eric H Holbrook, MD; Chief Editor: Arlen D Meyers, MD, MBA  more...
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Answer

Answer

Five different taste qualities—salty, sweet, sour, bitter, and umami (monosodium glutamate/5' nucleotide)—have been identified. In addition, there is evidence that another taste perception exists, the ability to sense lipid content. Similar to odorant transmission, most tastes are mediated by various GPCRs. Sweet, umami, and bitter are detected by members of 2 GPCR families, taste 1 receptor family (TAS1R) and taste 2 receptor family (TAS2R). Lipid content is mediated by a free fatty acid receptor. In contrast, sour and salty are mainly mediated by ion channels. [8]


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