How can healing time be improved in traumatic tympanic membrane perforation (TMP), and are systemic antibiotics needed for otorrhea?

Updated: Dec 14, 2020
  • Author: Robert A Saadi, MD; Chief Editor: Arlen D Meyers, MD, MBA  more...
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A retrospective study of patients with traumatic TMP greater than one quarter the size of the membrane found that topical application of either epidermal growth factor (EGF) or ofloxacin otic drops reduced healing time over that associated with observation. Healing with EGF and ofloxacin otic drops took a mean 12.6 and 12.9 days, respectively, compared with 35.7 days for observation. The actual closure rates for the three treatment methods, however, did not differ significantly. [23]

Systemic antibiotics are generally not needed when controlling otorrhea from a TMP, given the ease with which topical antibiotics can be administered.

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