Which studies are performed in a full metastatic workup of primitive neuroectodermal tumors (PNETs)?

Updated: Feb 07, 2019
  • Author: Carlo P Honrado, MD, FACS; Chief Editor: Arlen D Meyers, MD, MBA  more...
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Because of the high incidence of metastatic disease at presentation, a full metastatic workup is indicated in a suspected case of pPNET, including chest radiography, CT scanning of the chest, and a bone marrow biopsy. Furthermore, because pPNET is diagnosed based on biopsy findings, more extensive investigations, such as a technetium 99m bone scan or positron emission tomography (PET) scan, may be indicated. Other adjunctive studies include testing for urinary catecholamines and their metabolites, which are positive in patients with neuroblastoma but negative in patients with PNET and Ewing family of tumors (EFTs).

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