What are the signs and symptoms of primitive neuroectodermal tumors (PNETs)?

Updated: Feb 07, 2019
  • Author: Carlo P Honrado, MD, FACS; Chief Editor: Arlen D Meyers, MD, MBA  more...
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Clinical symptoms depend on the site of presentation but invariably include pain and swelling of the surrounding structures due to mass effect. Other reported symptoms and signs are site specific, including individual cranial neuropathies, exophthalmos, epistaxis, nasal obstruction, anosmia, neck masses, and headache (see the image below).

Photomicrograph shows characteristic cytoplasmic C Photomicrograph shows characteristic cytoplasmic CD-99 staining in peripheral primitive neuroectodermal tumor.

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