What is the usual spread pattern of Merkel cell carcinoma (MCC)?

Updated: Jan 18, 2019
  • Author: Arjun S Joshi, MD; Chief Editor: Arlen D Meyers, MD, MBA  more...
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MCCs are aggressive malignancies with courses more similar to those of malignant melanomas than to those of other skin cancers. Similar to melanoma, MCC has a high propensity for local recurrence, spread to regional lymph nodes, and distant metastasis.

MCC spreads in a predictable fashion. Initial spread is to first-echelon lymph nodes. Subsequent spread involves higher-order nodal regions and then distant sites.

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