What is the role of CT scanning in the diagnosis of Merkel cell carcinoma (MCC)?

Updated: Jan 18, 2019
  • Author: Arjun S Joshi, MD; Chief Editor: Arlen D Meyers, MD, MBA  more...
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Computed tomography /positron emission tomography

CT has a limited role in the evaluation of localized disease.

CT may reveal regional nodal involvement, or systemic involvement with metastases to the lung, bone, liver, etc. The sensitivity, specificity, positive predictive value, and negative predictive value of CT for regional lymph node involvement is 47%, 97%, 94%, and 68%, respectively. Sensitivity is increased 83% using18 F-Fluorodeoxyglucose (FDG) positron emission tomography (PET). [18] FDG-PET/CT can also uncover metastatic disease (mostly to bone/bone marrow) that is undetected on CT. [19]

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