What are the NCCN diagnostic guidelines for medullary thyroid carcinoma?

Updated: May 09, 2018
  • Author: Pramod K Sharma, MD; Chief Editor: Arlen D Meyers, MD, MBA  more...
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Answer

Answer

The NCCN recommends the following diagnostic procedures when FNAB results indicate medullary thyroid carcinoma [33] :

  • Basal serum calcitonin level
  • CEA level
  • Pheochromocytoma screening
  • Serum calcium assay
  • Consider genetic counseling
  • Screen for  RET proto-oncogene mutations (exons 10, 11, 13-16)
  • Thyroid and neck ultrasonography (including central and lateral compartments), if not previously done
  • Consider evaluation of vocal cord mobility
  • Consider contrast-enhanced CT scan of chest and mediastinum or MRI scan if N1 disease or calcitonin >400 pg/mL

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