What is the role of lab testing in the diagnosis of allergic fungal sinusitis (AFS)?

Updated: Apr 13, 2020
  • Author: John E McClay, MD; Chief Editor: Arlen D Meyers, MD, MBA  more...
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Total immunoglobulin E (IgE) values generally are elevated in allergic fungal sinusitis (AFS), often to more than 1000 U/mL (normal values are

Patients with allergic fungal sinusitis (AFS) generally demonstrate positive skin tests and in vitro radioallergosorbent test (RAST) responses to fungal and nonfungal antigens. Preliminary information suggests that methods of quantitative skin testing (in vivo) may provide even greater sensitivity ratings than RAST in patients with the disease.

Gell and Coombs type I hypersensitivity in patients with allergic fungal sinusitis (AFS) can be demonstrated by elevation of serum total and fungal-specific IgE and by positive skin test results for fungal and nonfungal antigens. However, this reaction does not appear to be fungal specific.

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