Which medications in the drug class Antihistamines are used in the treatment of Allergic Rhinitis in Otolaryngology and Facial Plastic Surgery?

Updated: Jan 02, 2019
  • Author: Quoc A Nguyen, MD; Chief Editor: Arlen D Meyers, MD, MBA  more...
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Answer

Antihistamines

These medications are H1 receptor antagonists and relieve sneezing, itching, and rhinorrhea.

Chlorpheniramine (Chlor-Trimeton, Aller-Chlor, Chlo-Amine)

A representative first-generation antihistamine; competes with histamine for H1 receptor sites on effector cells in blood vessels and in the respiratory tract.

Loratadine (Claritin)

Selectively inhibits peripheral histamine H1 receptors.

Fexofenadine (Allegra)

A representative third-generation antihistamine; competes with histamine for H1 receptors in the GI tract, blood vessels, and respiratory tract, reducing hypersensitivity reactions; does not cause sedation.

Azelastine (Astelin)

Topical antihistamine nasal spray; competes with histamine for H1 receptor sites in the blood vessels, GI tract, and respiratory tract.

Desloratadine (Clarinex)

Long-acting tricyclic histamine antagonist selective for H1 receptor. Relieves nasal congestion and systemic effects of seasonal allergy. Is a major metabolite of loratadine, which, after ingestion, is metabolized extensively to active metabolite 3-hydroxydesloratadine.

Olopatadine (Patanol)

Topical antihistamine ophthalmic solution.


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