Which medications in the drug class Antiemetic Agents are used in the treatment of Postconcussion Syndrome?

Updated: Sep 24, 2018
  • Author: Eric L Legome, MD; Chief Editor: Trevor John Mills, MD, MPH  more...
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Answer

Antiemetic Agents

Antiemetics are useful in the treatment of nausea associated with postconcussive syndrome.

Metoclopramide (Metozolv ODT, Reglan)

Metoclopramide blocks dopamine receptors in the chemoreceptor trigger zone of the central nervous system.

Ondansetron (Zofran, Zofran ODT, Zuplenz)

Ondansetron is a selective 5-HT3-receptor antagonist that blocks serotonin both peripherally and centrally. It prevents the nausea and vomiting.

Prochlorperazine (Compazine, Compro)

Prochlorperazine may relieve nausea and vomiting by blocking postsynaptic mesolimbic dopamine receptors through its anticholinergic effects and depressing the reticular activating system.


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