What is the role of serum caffeine concentration is the diagnosis and treatment of caffeine toxicity?

Updated: Oct 24, 2020
  • Author: David Yew, MD; Chief Editor: Michael A Miller, MD  more...
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Serum caffeine concentration determinations do not influence management. Consider the following:

  • Caffeine tests are generally available only at reference or research laboratories and are not clinically useful.

  • Serum theophylline concentrations are more rapidly and widely available than caffeine determinations. Because theophylline is a minor metabolite of caffeine, a positive theophylline assay may be helpful in confirming suspected caffeine toxicity. [24]

  • Patients with severe caffeine toxicity have had serum theophylline concentrations in the therapeutic range (10-20 mg/L).

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